Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats

被引：243
|
作者：
Thompson, Nancy L. [1 ]
Bazoberry, Fernando [2 ,3 ]
Speir, Edith H. [2 ]
Casscells, Ward [2 ]
Ferrans, Victor J. [3 ]
Flanders, Kathleen C. [1 ]
Kondaiah, Patljru
Geiser, Andrew G.
Sporn, Michael B. [1 ]
机构：
[1] NCI, Lab Chernoprevent, Bethesda, MD 20892 USA
[2] NHLBI, Cardiol, NIH, Bethesda, MD 20892 USA
[3] NHLBI, Pathol Branches, NIH, Bethesda, MD 20892 USA
来源：
GROWTH FACTORS | 1988年 / 1卷 / 01期
关键词：
Transforming growth factor-beta; myocardial infarction; heart; myocyte;
D O I：
10.3109/08977198809000251
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TGF-beta 1 has been examined in the heart during myocardial infarction caused by ligation of the left coronary artery. Infarcted and uninfarcted myocardium have been compared by immunohistochemical staining of TGF-beta 1 and by Northern blot analysis of mRNA. Normal ventricular myocytes are strongly stained by an antibody to TGF-beta 1l. Progressive loss of staining of these myocytes begins within 1hr after coronary ligation. However, by 24-48 hr after ligation, intense staining of myocytes at the margin of infarcted areas is seen. Northern blots of infarcted myocardium 48 hr after ligation show a 3- to 4-fold increase in the principal 2.4 kb TGF-beta 1 mRNA; there is also a marked increase in a minor 1.9 kb transcript. In the same tissue samples, there is a 2-fold decrease in the mRNA for the glycolytic enzyme, glyceraldehyde-3-phosphatedehydrogenase. The results indicate a significant role for TGF-beta 1 in the response of the heart to injury.
引用
收藏
页码：91 / 99
页数：9
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