Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats

被引：243

作者：

Thompson, Nancy L. ^{[1
]}

Bazoberry, Fernando ^{[2
,3
]}

Speir, Edith H. ^{[2
]}

Casscells, Ward ^{[2
]}

Ferrans, Victor J. ^{[3
]}

Flanders, Kathleen C. ^{[1
]}

Kondaiah, Patljru

Geiser, Andrew G.

Sporn, Michael B. ^{[1
]}

机构：

[1] NCI, Lab Chernoprevent, Bethesda, MD 20892 USA

[2] NHLBI, Cardiol, NIH, Bethesda, MD 20892 USA

[3] NHLBI, Pathol Branches, NIH, Bethesda, MD 20892 USA

来源：

GROWTH FACTORS | 1988年 / 1卷 / 01期

关键词：

Transforming growth factor-beta; myocardial infarction; heart; myocyte;

D O I：

10.3109/08977198809000251

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta 1 has been examined in the heart during myocardial infarction caused by ligation of the left coronary artery. Infarcted and uninfarcted myocardium have been compared by immunohistochemical staining of TGF-beta 1 and by Northern blot analysis of mRNA. Normal ventricular myocytes are strongly stained by an antibody to TGF-beta 1l. Progressive loss of staining of these myocytes begins within 1hr after coronary ligation. However, by 24-48 hr after ligation, intense staining of myocytes at the margin of infarcted areas is seen. Northern blots of infarcted myocardium 48 hr after ligation show a 3- to 4-fold increase in the principal 2.4 kb TGF-beta 1 mRNA; there is also a marked increase in a minor 1.9 kb transcript. In the same tissue samples, there is a 2-fold decrease in the mRNA for the glycolytic enzyme, glyceraldehyde-3-phosphatedehydrogenase. The results indicate a significant role for TGF-beta 1 in the response of the heart to injury.

引用

页码：91 / 99

页数：9

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