ASYMMETRIC-SYNTHESIS OF (-)-NEOPODOPHYLLOTOXIN

被引：53

作者：

CHARLTON, JL

KOH, K

机构：

[1] Department of Chemistry, University of Manitoba, Winnipeg, Manitoba

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 05期

关键词：

D O I：

10.1021/jo00031a033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A five-step asymmetric synthesis of neopodophyllotoxin in 18% overall yield and optical purity > 97%, starting from 6-(3,4,5-trimethoxybenzyl)piperonal (6) and the fumarate of (S)-methyl mandelate (8), is described.

引用

页码：1514 / 1516

页数：3

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