HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)

被引：85
|
作者：
KIOKA, N [1 ]
YAMANO, Y [1 ]
KOMANO, T [1 ]
UEDA, K [1 ]
机构：
[1] KYOTO UNIV,DEPT AGR CHEM,BIOCHEM LAB,KYOTO 606,JAPAN
来源：
FEBS LETTERS | 1992年 / 301卷 / 01期
关键词：
MULTIDRUG RESISTANCE; MDR1; P-GLYCOPROTEIN; HEAT-SHOCK PROTEIN;
D O I：
10.1016/0014-5793(92)80205-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.
引用
收藏
页码：37 / 40
页数：4
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