Multidrug Resistance 1 (MDR1) Gene Polymorphisms in Childhood Drug-Resistant Epilepsy

被引：29

作者：

Alpman, Asude ^{[1
]}

Ozkinay, Ferda ^{[2
]}

Tekgul, Hasan ^{[3
]}

Gokben, Sarenur ^{[3
]}

Pehlivan, Sacide ^{[4
]}

Schalling, Martin ^{[5
]}

Ozkinay, Cihangir ^{[1
]}

机构：

[1] Ege Univ, Fac Med, Dept Med Genet, Izmir, Turkey

[2] Ege Univ, Fac Med, Dept Pediat, Subdiv Genet & Teratol, Izmir, Turkey

[3] Ege Univ, Fac Med, Dept Pediat, Subdiv Neurol, Izmir, Turkey

[4] Ege Univ, Fac Med, Dept Biol, Izmir, Turkey

[5] Karolinska Inst, Ctr Mol Med, Dept Neurosci, Stockholm, Sweden

来源：

JOURNAL OF CHILD NEUROLOGY | 2010年 / 25卷 / 12期

关键词：

drug-resistant epilepsy; MDR1; gene; polymorphism; P-GLYCOPROTEIN; C3435T POLYMORPHISM; ASSOCIATION; ABCB1; EXPRESSION; PHARMACORESISTANCE; PHARMACOKINETICS; TRANSPORTERS; HAPLOTYPE; GENOTYPE;

D O I：

10.1177/0883073810368997

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite considerable progress in the pharmacotherapy of epilepsy, more than 30% of patients are reported to be resistant to antiepileptic drugs. Multidrug resistance 1 (MDR1) gene could play a role in drug resistance in epilepsy. In this study, the authors investigated the association between the MDR1 gene polymorphisms, C3435T and G2677AT, and drug resistance epilepsy by using polymerase chain reaction/restriction fragment length polymorphism and pyrosequencing methods in a group of 39 patients with drug-resistant epilepsy and 92 controls. No associations were found between the polymorphisms of the MDR1 gene and drug-resistant epilepsy. Haplotype analysis showed no significant association. Compound genotype analysis showed that CC3435/GG2677 was significantly higher in the control group compared to the patient group. In conclusion, MDR1 polymorphisms investigated in this study are not associated with antiepileptic drug resistance, but the CC3435/GG2677 compound genotype might have an effect on antiepileptic drug response.

引用

页码：1485 / 1490

页数：6

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