ASSOCIATION OF TYPE-I PHOSPHATIDYLINOSITOL KINASE-ACTIVITY WITH MUTATIONALLY ACTIVATED FORMS OF HUMAN PP60C-SRC

被引：29
|
作者：
CHAN, TO
TANAKA, A
BJORGE, JD
FUJITA, DJ
机构：
[1] UNIV CALGARY,CTR MED SCI,DEPT MED BIOCHEM,CELL REGULAT GRP,CALGARY T2N 4N1,ALBERTA,CANADA
[2] CTR MOLEC MED & IMMUNOL,NEWARK,NJ 07103
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期
关键词：
D O I：
10.1128/MCB.10.6.3280
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chicken embryo fibroblast cells overexpressing activated mutant forms of human ppd60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.
引用
收藏
页码：3280 / 3283
页数：4
相关论文
共 50 条
  • [31] PP60C-SRC IN HUMAN MELANOCYTES AND MELANOMA-CELLS EXHIBITS ELEVATED SPECIFIC ACTIVITY AND REDUCED TYROSINE-530 PHOSPHORYLATION COMPARED TO HUMAN FIBROBLAST PP60C-SRC
    OCONNOR, TJ
    NEUFELD, E
    BECHBERGER, J
    FUJITA, DJ
    CELL GROWTH & DIFFERENTIATION, 1992, 3 (07): : 435 - 442
  • [32] PREFERENTIAL EXPRESSION OF A PP60C-SRC RELATED PROTEIN TYROSINE KINASE-ACTIVITY IN NERVE-CELLS OF THE EARLY METAZOAN HYDRA (COELENTERATES)
    SCHARTL, M
    HOLSTEIN, T
    ROBERTSON, SM
    BARNEKOW, A
    ONCOGENE, 1989, 4 (10) : 1185 - 1191
  • [33] PHOSPHATIDYLINOSITOL KINASE-ACTIVITY ASSOCIATES WITH VIRAL P60SRC PROTEIN
    FUKUI, Y
    HANAFUSA, H
    MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (04) : 1651 - 1658
  • [34] A PROTEIN TYROSINE KINASE INVOLVED IN REGULATION OF PP60C-SRC FUNCTION
    OKADA, M
    NAKAGAWA, H
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (35) : 20886 - 20893
  • [35] ACTIVATION OF THE PP60C-SRC PROTOONCOGENE IN HUMAN-CELLS
    ROSEN, N
    BOLEN, JB
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 17 - 17
  • [36] INTRACELLULAR-LOCALIZATION OF PP60C-SRC IN HUMAN PLATELETS
    FERRELL, JE
    NOBLE, JA
    MARTIN, GS
    JACQUES, YV
    BAINTON, DF
    ONCOGENE, 1990, 5 (07) : 1033 - 1036
  • [37] PP60C-SRC ACTIVATION IN HUMAN-COLON CARCINOMA
    CARTWRIGHT, CA
    KAMPS, MP
    MEISLER, AI
    PIPAS, JM
    ECKHART, W
    JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (06): : 2025 - 2033
  • [38] Novel Aminomethylindole Derivatives as Inhibitors of pp60c-Src Tyrosine Kinase: Synthesis and Biological Activity
    Isgor, Yasemin G.
    Kilic, Zuhal
    Olgen, Sureyya
    CHEMICAL BIOLOGY & DRUG DESIGN, 2008, 72 (06) : 599 - 604
  • [39] INCREASED TYROSINE KINASE-ACTIVITY IN PP60C-SRC IMMUNOPRECIPITATE FROM PLATELET-ACTIVATING-FACTOR STIMULATED HUMAN PLATELETS - INVITRO PHOSPHORYLATION OF A SYNTHETIC PEPTIDE
    ZHU, CY
    SHUKLA, SD
    LIFE SCIENCES, 1993, 53 (02) : 175 - 183
  • [40] SITE-SPECIFIC DIFFERENCES IN PP60C-SRC ACTIVITY IN HUMAN COLORECTAL METASTASES
    TERMUHLEN, PM
    CURLEY, SA
    TALAMONTI, MS
    SABOORIAN, MH
    GALLICK, GE
    JOURNAL OF SURGICAL RESEARCH, 1993, 54 (04) : 293 - 298
12345