ASSOCIATION OF TYPE-I PHOSPHATIDYLINOSITOL KINASE-ACTIVITY WITH MUTATIONALLY ACTIVATED FORMS OF HUMAN PP60C-SRC

被引：29
|
作者：
CHAN, TO
TANAKA, A
BJORGE, JD
FUJITA, DJ
机构：
[1] UNIV CALGARY,CTR MED SCI,DEPT MED BIOCHEM,CELL REGULAT GRP,CALGARY T2N 4N1,ALBERTA,CANADA
[2] CTR MOLEC MED & IMMUNOL,NEWARK,NJ 07103
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期
关键词：
D O I：
10.1128/MCB.10.6.3280
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chicken embryo fibroblast cells overexpressing activated mutant forms of human ppd60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway.
引用
收藏
页码：3280 / 3283
页数：4
相关论文
共 50 条
  • [21] Structural basis for the activity of pp60c-src protein tyrosine kinase inhibitors
    Prabhu, NV
    Siddiqui, SA
    McMurray, JS
    Pettitt, BM
    BIOPOLYMERS, 2001, 59 (03) : 167 - 179
  • [22] pp60c-src protein tyrosine kinase expression in human B lymphocytes
    Branch, DR
    Ma, XZ
    Sakac, D
    Roy, A
    Néron, S
    IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY, 2004, : 129 - 134
  • [23] Reduced C-terminal Src kinase activity is correlated inversely with pp60c-src activity in colorectal carcinoma
    Cam, WR
    Masaki, T
    Shiratori, Y
    Kato, N
    Ikenoue, T
    Okamoto, M
    Igarashi, K
    Sano, T
    Omata, M
    CANCER, 2001, 92 (01) : 61 - 70
  • [24] ANALYSIS OF PP60C-SRC TYROSINE KINASE-ACTIVITY AND PHOSPHOTYROSYL PHOSPHATASE-ACTIVITY IN HUMAN-COLON CARCINOMA AND NORMAL HUMAN-COLON MUCOSAL CELLS
    DESEAU, V
    ROSEN, N
    BOLEN, JB
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, 35 (02) : 113 - 128
  • [25] Identification and characterization of a novel pp60c-Src kinase inhibitory activity in adult cardiocytes
    Kasi, VS
    Kuppuswamy, D
    CIRCULATION, 1996, 94 (08) : 2384 - 2384
  • [26] EXPRESSION OF ACTIVATED HUMAN PP60C-SRC IN MAMMARY-GLANDS OF TRANSGENIC MICE
    GILMER, TM
    ALLIGOOD, KJ
    LUTTRELL, DK
    RUSNAK, DW
    KUCERA, GT
    ROSENBERG, MP
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 16 - 16
  • [27] ASSOCIATION OF PP60C-SRC WITH THE CYTOSKELETON UPON PLATELET ACTIVATION
    HORVATH, AR
    KISS, Z
    ANAND, R
    KELLIE, S
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (04) : 1150 - 1154
  • [28] Association of pp60c-src with αIIbβ3 in resting platelets
    Kralisz, U
    Cierniewski, CS
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 45 (04): : 735 - 743
  • [29] CHARACTERIZATION OF PURIFIED PP60C-SRC PROTEIN TYROSINE KINASE FROM HUMAN PLATELETS
    REUTER, C
    FINDIK, D
    PRESEK, P
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 190 (02): : 343 - 350
  • [30] Activity of pp60c-src and association of pp60-src, pp54/58lyn, pp60fyn, and pp72syk with the cytoskeleton in platelets activated by collagen
    Kralisz, U
    Cierniewski, CS
    IUBMB LIFE, 2000, 49 (01) : 33 - 42
12345