IDENTIFICATION OF ABNORMAL CHROMOSOMAL COMPLEMENT IN FORMALIN-FIXED, PARAFFIN-EMBEDDED PLACENTAL TISSUE

被引：9
|
作者：
COWLES, TA
ELDER, FFB
TAYLOR, S
机构：
[1] UNIV TEXAS,HLTH SCI CTR,DEPT OBSTET GYNECOL & REPROD SCI,HOUSTON,TX
[2] UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,HOUSTON,TX
来源：
PRENATAL DIAGNOSIS | 1995年 / 15卷 / 01期
关键词：
FLUORESCENCE IN SITU HYBRIDIZATION (FISH); FORMALIN-FIXED PLACENTA; KARYOTYPE;
D O I：
10.1002/pd.1970150106
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The objective of this project was to assess the efficacy of fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes to identify chromosome number in formalin-fixed, paraffin-embedded placental specimens. Using this approach, 75 per cent of the karyotypes in 20 formalin-fixed placental samples (comprising aneuploids, triploids, and normals) were correctly identified. As this technology improves, the ability to obtain information regarding chromosomal abnormalities in formalin-fixed, paraffin-embedded placental tissue should improve as well. This technology can potentially provide important cytogenetic information even when fresh tissue is not available for standard karyotypic analysis.
引用
收藏
页码：21 / 26
页数：6
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