INHIBITORS OF PROTEIN-KINASES INDUCE DIFFERENTIATION IN HUMAN NEUROBLASTOMA CELL-LINES

被引：0
|
作者：
ROCCHI, P
FERRERI, AM
SIMONE, G
MAGRINI, E
CAVALLAZZI, L
PAOLUCCI, G
机构：
[1] CNR,IST FRAE,I-40126 BOLOGNA,ITALY
[2] UNIV BOLOGNA,CTR INTERDIPARTIMENTALE RIC CANC GIORGIO PRODI,I-40138 BOLOGNA,ITALY
来源：
ANTICANCER RESEARCH | 1995年 / 15卷 / 04期
关键词：
NEUROBLASTOMA; DIFFERENTIATION; PROTEIN-KINASES INHIBITORS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the effect on differentiation of genistein, an inhibitor of tyrosine protein kinase, and 1-(-5 isoquinolinylsulfonyl)-2-methylpiperazine (H7), an inhibitor of protein kinase C, in neuroblastoma cell lines. Growth inhibition and expression of morphological and biochemical properties were examined in the human neuroblastoma cell lines TS12 and SJNKP. Genistein and H7 induced neurite outgrowth, increased acetylcholinesterase activity and cell growth inhibition in both cell lines. These results underline that tyrosine protein kinase and protein kinase C may play a key role in the cona ol of differentiation and proliferation of neural cells.
引用
收藏
页码：1381 / 1385
页数：5
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