INHIBITORS OF PROTEIN-KINASES INDUCE DIFFERENTIATION IN HUMAN NEUROBLASTOMA CELL-LINES

被引：0

作者：

ROCCHI, P

FERRERI, AM

SIMONE, G

MAGRINI, E

CAVALLAZZI, L

PAOLUCCI, G

机构：

[1] CNR,IST FRAE,I-40126 BOLOGNA,ITALY

[2] UNIV BOLOGNA,CTR INTERDIPARTIMENTALE RIC CANC GIORGIO PRODI,I-40138 BOLOGNA,ITALY

来源：

ANTICANCER RESEARCH | 1995年 / 15卷 / 04期

关键词：

NEUROBLASTOMA; DIFFERENTIATION; PROTEIN-KINASES INHIBITORS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the effect on differentiation of genistein, an inhibitor of tyrosine protein kinase, and 1-(-5 isoquinolinylsulfonyl)-2-methylpiperazine (H7), an inhibitor of protein kinase C, in neuroblastoma cell lines. Growth inhibition and expression of morphological and biochemical properties were examined in the human neuroblastoma cell lines TS12 and SJNKP. Genistein and H7 induced neurite outgrowth, increased acetylcholinesterase activity and cell growth inhibition in both cell lines. These results underline that tyrosine protein kinase and protein kinase C may play a key role in the cona ol of differentiation and proliferation of neural cells.

引用

页码：1381 / 1385

页数：5

共 50 条

[1] INVITRO INVESTIGATION OF DIFFERENTIATION OF NEUROBLASTOMA CELL-LINES WITH A HYPOTHALAMIC PROTEIN (HP)
BUSSE, E
GEREIN, V
KORNHUBER, B
EUROPEAN JOURNAL OF CELL BIOLOGY, 1986, 42 : 28 - 28
[2] EXPRESSION AND DISTRIBUTION OF PERIPHERIN PROTEIN IN HUMAN NEUROBLASTOMA CELL-LINES
PEDERSEN, WA
BECKER, LE
YEGER, H
INTERNATIONAL JOURNAL OF CANCER, 1993, 53 (03) : 463 - 470
[3] ACTIVATION OF MURINE MACROPHAGE CELL-LINES - POSSIBLE INVOLVEMENT OF PROTEIN-KINASES IN STIMULATION OF SUPEROXIDE PRODUCTION
KIYOTAKI, C
BLOOM, BR
JOURNAL OF IMMUNOLOGY, 1984, 133 (02): : 923 - 931
[4] INTERRELATION BETWEEN RETINOIC ACID AND CAMP-DEPENDENT PROTEIN-KINASES IN TERATOCARCINOMA CELL-LINES
PLET, A
SHERMAN, M
ANDERSON, WB
EVAINBRION, D
DERMATOLOGICA, 1984, 169 (04): : 228 - 228
[5] INHIBITORS OF PROTEIN-KINASES AND PHOSPHATASES
MACKINTOSH, C
MACKINTOSH, RW
TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (11) : 444 - 448
[6] Low levels of mycophenolic acid induce differentiation of human neuroblastoma cell lines
Messina, E
Gazzaniga, P
Micheli, V
Barile, L
Lupi, F
Aglianò, AM
Giacomello, A
INTERNATIONAL JOURNAL OF CANCER, 2004, 112 (02) : 352 - 354
[7] PROTEIN-KINASE-C INHIBITORS INDUCE APOPTOSIS IN HUMAN-MALIGNANT GLIOMA CELL-LINES
COULDWELL, WT
HINTON, DR
HE, SK
CHEN, TC
SEBAT, I
WEISS, MH
LAW, RE
FEBS LETTERS, 1994, 345 (01) : 43 - 46
[8] STUDIES ON PROTEIN-KINASES IN 2 HUMAN RECTOCOLIC CELL-LINES BY POLYACRYLAMIDE-GEL ELECTROPHORESIS - EFFECT OF THE VASOACTIVE INTESTINAL PEPTIDE
MANGEAT, P
AITAHMED, O
MARCHISMOUREN, G
MARVALDI, J
BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 714 (02) : 320 - 330
[9] EFFECTS OF HOMOHARINGTONINE ON HUMAN NEUROBLASTOMA CELL-LINES
TEBBI, CK
CHERVINSKY, D
MURPHY, T
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1987, 28 : 425 - 425
[10] ROLE OF PROTEIN-KINASES IN MAMMARY EPITHELIAL-CELL DIFFERENTIATION
HYNES, N
MARTE, B
TAVERNA, D
JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 234 - 234

← 1 2 3 4 5 →