INHIBITORS OF PROTEIN-KINASES AND PHOSPHATASES

被引：228

作者：

MACKINTOSH, C

MACKINTOSH, RW

机构：

[1] C. MacKintosh and R.W. MacKintosh are, the Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, Dundee

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90127-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibitors of eukaryotic protein kinases and phosphatases are a chemically diverse array of natural and synthetic compounds, including medicines, potions and poisons. These substances are valuable pharmacological probes and affinity ligands for the kinases and phosphatases of signalling pathways, enhancing our knowledge of the cellular effects of the pathway in question. More broadly, this basic research is also leading to the development of drugs to control specific cellular responses, and enzyme-based assays to detect toxins in food and water.

引用

页码：444 / 448

页数：5

共 50 条

[1] PROTEIN-KINASES AND PHOSPHATASES - STRUCTURAL BIOLOGY AND SYNTHETIC INHIBITORS
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[J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 29, 1994, 29 : 255 - 264
[2] VIRAL PROTEIN-KINASES AND PROTEIN PHOSPHATASES
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[J]. PHARMACOLOGY & THERAPEUTICS, 1993, 59 (03) : 343 - 389
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[5] INTRASTERIC REGULATION OF PROTEIN-KINASES AND PHOSPHATASES
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[8] PROTEIN-KINASES AND PHOSPHATASES - REGULATION BY AUTOINHIBITORY DOMAINS
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[9] ROUND-TABLE ON PROTEIN-KINASES AND PHOSPHATASES
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[10] EFFECTS OF PYRETHROIDS ON NEURAL PROTEIN-KINASES AND PHOSPHATASES
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