EFFECT OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON SURVIVAL IN LETHALLY IRRADIATED MICE

被引：25
|
作者：
HOSOI, Y
KURISHITA, A
ONO, T
SAKAMOTO, K
机构：
[1] Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai
来源：
ACTA ONCOLOGICA | 1992年 / 31卷 / 01期
关键词：
RADIATION; TOTAL BODY; MICE; GRANULOCYTE; COLONY-STIMULATING FACTOR (G-CSF); SURVIVAL;
D O I：
10.3109/02841869209088267
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Repeated injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5-mu-g/mouse of rhG-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhG-CSF increased the number of blood-circulating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhG-CSF treatment compared with the values for mice irradiated only.
引用
收藏
页码：59 / 63
页数：5
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