IN-VITRO EFFECT OF 5-FLUOROURACIL, VERAPAMIL AND HYPERTHERMIA ON THE HUMAN PANCREATIC ADENOCARCINOMA CELL-LINE ASPC-1

被引：8
|
作者：
SHCHEPOTIN, IB
BURAS, RR
NAUTA, RJ
SHABAHANG, M
SOLDATENKOV, VA
EVANS, SRT
机构：
[1] GEORGETOWN UNIV,VINCENT T LOMBARDI CANC RES CTR,WASHINGTON,DC 20007
[2] GEORGETOWN UNIV,DEPT SURG,WASHINGTON,DC 20007
来源：
CHEMOTHERAPY | 1994年 / 40卷 / 05期
关键词：
PANCREATIC CANCER; 5-FLUOROURACIL; VERAPAMIL; HYPERTHERMIA;
D O I：
10.1159/000239217
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this study was to assess the efficacy of verapamil (20 mu M) and hyperthermia (42 degrees C) as modifiers of 5-fluorouracil (5-FU) used at different concentrations, in inhibiting the growth of human pancreatic adenocarcinoma cells. Combined verapamil and hyperthermia treatment significantly decreased cell count by 63.8% when compared to the control. Verapamil drastically enhanced the growth inhibitory effect of 5-FU at all concentrations. At high-concentration 5-FU (50 mu g/ml), verapamil and hyperthermia had a synergistic growth-inhibitory effect and caused a significant decrease in cell count by 81.4% in comparison to the control. The modalities analyzed in this study require further investigation and have potential for clinical applicability to pancreatic cancer therapy in the future.
引用
收藏
页码：348 / 356
页数：9
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