COMPARISON OF THERAPEUTIC ROUTES IN EXPERIMENTAL PSEUDOMONAS KERATITIS

The efficacy of tobramycin administered by topical, i.m. and subconjunctival routes in guinea pigs and rabbits with experimental Pseudomonas keratitis was determined. The topical route of administration was consistently more effective than either subconjunctival or i.m. routes. Subconjunctival injection of antibiotic did not enhance the effectiveness of topical therapy in either guinea pigs or rabbits. Tobramycin i.m. was more effective than saline in guinea pigs with keratitis but not in rabbits with keratitis.