CLONING AND EXPRESSION OF THE CHICKEN CD18 CDNA

被引：13
|
作者：
BILSLAND, CAG
SPRINGER, TA
机构：
[1] HARVARD UNIV, CTR BLOOD RES, SCH MED, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 55卷 / 04期
关键词：
LFA-1; CHICKEN CD18 CDNA; LEUKOCYTE INTEGRINS;
D O I：
10.1002/jlb.55.4.501
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. We describe here the isolation and characterization of the chicken beta 2 (CD18) subunit, common to the leukocyte integrin family. The deduced 748-amino-acid sequence reveals a transmembrane protein with 65% and 64% identity with its human and murine homologues, respectively. The chicken beta 2 can associate on the cell surface with the human alpha subunit of LFA-1 and yields a hybrid molecule capable of binding to purified ICAM-1 and ICAM-3.
引用
收藏
页码：501 / 506
页数：6
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