Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin

被引：6
|
作者：
Espino-Solis, Gerardo P. [1 ]
Osuna-Quintero, Joel [2 ]
Possani, Lourival D. [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Dept Med Mol & Bioproc, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
[2] Univ Nacl Autonoma Mexico, Dept Ingn Celular & Biocatalisis, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2008年 / 122卷 / 3-4期
关键词：
antibody; CD11c; dendritic cells; horse; I-domain; integrin;
D O I：
10.1016/j.vetimm.2007.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This work reports the cloning and sequence determination of the horse alpha subunit of the integrin CD11c/CD18, a marker of dendritic cells. A cDNA clone of 4582 base pairs was obtained. It encodes a protein segment of 1086 amino acid residues of the extracellular domain with 10 potential sites of glycosylation, a transmembrane domain of 32 residues and a C-terminal cytoplasmic tail of 24 residues. A phylogenetic analysis of this integrin shows close similarity (83%) with that of Canis familiaris. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：326 / 334
页数：9
相关论文
共 50 条
  • [1] Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin
    Gerardo Pavel, Espino-Solis
    Quintero-Hernandez, Veronica
    Olvera-Rodriguez, Alejandro
    Calderon-Amador, Juana
    Pedraza-Escalona, Martha
    Licea-Navarro, Alexei
    Flores-Romo, Leopoldo
    Domingos Possani, Lourival
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2015, 164 (3-4) : 220 - 226
  • [2] Integrin CD11c/CD18 α-Chain Phosphorylation Is Functionally Important
    Uotila, Liisa M.
    Aatonen, Maria
    Gahmberg, Carl G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (46) : 33494 - 33499
  • [3] Binding between the Integrin αXβ2 (CD11c/CD18) and heparin
    Vorup-Jensen, Thomas
    Chi, Lianli
    Gjelstrup, Louise C.
    Jensen, Uffe B.
    Jewett, Craig A.
    Xie, Can
    Shimaoka, Motomu
    Linhardt, Robert J.
    Springer, Timothy A.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (42) : 30869 - 30877
  • [4] CD11c/CD18 Phosphorylation on Alpha Chain Regulates Integrin Functions
    Uotila, Liisa
    Aatonen, Maria
    Gahmberg, Carl
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2014, 79 (06) : 427 - 427
  • [5] THE ROLE OF THE CD11C/CD18 INTEGRIN FOR THE INTERACTION OF ACTIVATED PLATELETS AND NEUTROPHILS
    RUF, A
    PATSCHEKE, H
    THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 1130 - 1130
  • [6] Interaction of ICAM-1 with β2-integrin CD11c/CD18
    Frick, C
    Odermatt, A
    Zen, K
    Mandell, KJ
    Edens, H
    Portmann, R
    Mazzucchelli, L
    Jaye, DL
    Parkos, CA
    FASEB JOURNAL, 2005, 19 (04): : A269 - A269
  • [7] Monocyte integrin CD11c/CD18 is a functional biomarker for risk of cardiovascular disease
    Gower, R. Michael
    Wu, Huaizhu
    Knowlton, Anne A.
    Ballantyne, Christie M.
    Simon, Scott I.
    FASEB JOURNAL, 2009, 23
  • [8] REGULATED EXPRESSION AND FUNCTION OF CD11C/CD18 INTEGRIN ON HUMAN LYMPHOCYTES-B - RELATION BETWEEN ATTACHMENT TO FIBRINOGEN AND TRIGGERING OF PROLIFERATION THROUGH CD11C/CD18
    POSTIGO, AA
    CORBI, AL
    SANCHEZMADRID, F
    DELANDAZURI, MO
    JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06): : 1313 - 1322
  • [9] Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes
    Arndt, Stephanie
    Melle, Christian
    Mondal, Krishna
    Klein, Gerd
    von Eggeling, Ferdinand
    Bosserhoff, Anja-Katrin
    JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (06) : 1466 - 1472
  • [10] CD11C/CD18, A TRANSMEMBRANE SIGNALING RECEPTOR FOR LIPOPOLYSACCHARIDE
    INGALLS, RR
    GOLENBOCK, DT
    JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04): : 1473 - 1479
12345