TISSUE-TYPE TRANSGLUTAMINASE IS NOT A TUMOR-RELATED MARKER

被引：2

作者：

TAKAKU, K ^{[1
]}

FUTAMURA, M ^{[1
]}

SAITOH, S ^{[1
]}

TAKEUCHI, Y ^{[1
]}

机构：

[1] MERCK RES LAB,BANYU TSUKUBA RES INST,TSUKUBA,IBARAKI 30033,JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1995年 / 118卷 / 06期

关键词：

IMMUNOBLOTTING; TRANSGLUTAMINASE; TUMOR CELL;

D O I：

10.1093/oxfordjournals.jbchem.a125017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The level of transglutaminase (TGase) expressed in various tumor cell lines was investigated. We found that each cell line could be categorized into three distinct groups, that is, (i) cell lines with low or negligible TGase activity, (ii) cell lines with significant or high TGase activity and immunoreactive to a monoclonal antibody against tissue type TGase, and (iii) cell lines with significant or high TGase activity but not immunoreactive to the antibody. Results reported here argue against the former proposal that tissue-type TGase is expressed at a lower level in malignant cells compared to the level in normal cells.

引用

页码：1268 / 1270

页数：3

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