COMPARISON OF RUFLOXACIN AND NORFLOXACIN EFFECTS ON FECAL FLORA

被引：5
|
作者：
MARCO, F
GIMENEZ, MJ
DEANTA, MTJ
MARCOS, MA
SALVA, P
AGUILAR, L
机构：
[1] SMITHKLINE BEECHAM SA, DEPT MED, E-28034 MADRID, SPAIN
[2] HOSP GERMANS TRIAS & PUJOL, DEPT CLIN PHARMACOL, E-08916 BADALONA, SPAIN
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 06期
关键词：
D O I：
10.1093/jac/35.6.895
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused >70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).
引用
收藏
页码：895 / 901
页数：7
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