CHARACTERISTICS AND SUBCELLULAR-LOCALIZATION OF PRISTANOYL-COA SYNTHETASE IN RAT-LIVER

被引：32
|
作者：
WANDERS, RJA
DENIS, S
VANROERMUND, CWT
JAKOBS, C
TENBRINK, HJ
机构：
[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN BIOCHEM FO226,1105 AZ AMSTERDAM,NETHERLANDS
[2] FREE UNIV AMSTERDAM,DEPT PEDIAT,1007 MC AMSTERDAM,NETHERLANDS
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1125卷 / 03期
关键词：
PRISTANIC ACID; PHYTANIC ACID; PEROXISOME; PEROXISOMAL DISORDER; FATTY ACID OXIDATION; (RAT LIVER);
D O I：
10.1016/0005-2760(92)90056-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have investigated the activation of pristanic acid to its CoA-ester in rat liver. The results show that peroxisomes, mitochondria as well as microsomes contain pristanoyl-CoA synthetase activity. On the basis of competition experiments and immunoprecipitation studies using antibodies raised against rat liver microsomal long-chain fatty acyl-CoA synthetase (EC 6.2.1.3) we conclude that pristanic acid is activated by the same enzyme which activates long-chain fatty acids, i.e., long-chain fatty acyl-CoA synthetase.
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页码：274 / 279
页数：6
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