STEREOCONTROLLED CONVERGENT SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES BY THE REACTION OF ALPHA-AMINO ALDEHYDE WITH ALKOXYTITANIUM HOMOENOLATES

被引：33

作者：

KANO, S ^{[1
]}

YOKOMATSU, T ^{[1
]}

SHIBUYA, S ^{[1
]}

机构：

[1] TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 02期

关键词：

D O I：

10.1016/0040-4039(91)80863-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of (S)-alpha-dibenzylamino aldehydes with dichloroisopropoxy-titanium ester homoenolates gave the corresponding gamma-aminoalkyl gamma-lactones with high erythro selectivity. The same reaction by the use of amide homoenolates also afforded the corresponding 2-amino alcohols with high erythro-selectivity.

引用

页码：233 / 236

页数：4

共 49 条

[21] 2-THIAZOLYL ALPHA-AMINO KETONES - A NEW CLASS OF REACTIVE INTERMEDIATES FOR THE STEREOCONTROLLED SYNTHESIS OF UNUSUAL AMINO-ACIDS
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PERRONE, D
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[23] CRCL2 MEDIATED ALLYLATION OF N-PROTECTED ALPHA-AMINO ALDEHYDES - A VERSATILE SYNTHESIS OF POLYPEPTIDES CONTAINING AN HYDROXYETHYLENE ISOSTERE
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[26] A SIMPLE, CHIRAL-POOL-INDEPENDENT SYNTHESIS OF ENANTIOMERICALLY PURE ALANINE-DERIVED ALPHA-AMINO ALDEHYDE ACETALS
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[27] Tetramethyl guanidine (TMG) catalyzed synthesis of novel alpha-amino phosphonates by one-pot reaction
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