POSTTRANSCRIPTIONAL REGULATION OF CYTOSKELETAL ACTIN AND LYMPHOCYTE-T RECEPTOR BETA-CHAIN MESSENGER-RNA BY PHORBOL ESTER

被引：6

作者：

GOODIER, MR ^{[1
]}

KAY, JE ^{[1
]}

机构：

[1] UNIV SUSSEX, SCH BIOL SCI, BIOCHEM LAB, BRIGHTON BN1 9RH, E SUSSEX, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1092卷 / 01期

关键词：

REGULATION; ACTIN; MESSENGER RNA; PHORBOL ESTER; T-CELL ANTIGEN RECEPTOR; PROTEIN KINASE-C; CYCLOSPORINE-A;

D O I：

10.1016/0167-4889(91)90186-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein kinase C activator phorbol 12-myristate 13-acetate (TPA) augments the level of cytoplasmic mRNA for cytoskeletal actin and the beta chain of the T cell antigen receptor (TCR-beta) in peripheral blood lymphocytes. Calcium ionophore A23187 has an antagonistic effect on these increases. The immunosuppressive drug cyclosporin A blocked both positive and negative effects of A23187 without affecting those of TPA. TPA-mediated increases in cytoplasmic corresponding total cellular RNA. Activation of protein kinase C can thus mediate the accumulation of these mRNAs by a post-transcriptional mechanism.

引用

页码：124 / 127

页数：4

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