POSTTRANSCRIPTIONAL REGULATION OF CYTOSKELETAL ACTIN AND LYMPHOCYTE-T RECEPTOR BETA-CHAIN MESSENGER-RNA BY PHORBOL ESTER

被引：6
|
作者：
GOODIER, MR [1 ]
KAY, JE [1 ]
机构：
[1] UNIV SUSSEX, SCH BIOL SCI, BIOCHEM LAB, BRIGHTON BN1 9RH, E SUSSEX, ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1092卷 / 01期
关键词：
REGULATION; ACTIN; MESSENGER RNA; PHORBOL ESTER; T-CELL ANTIGEN RECEPTOR; PROTEIN KINASE-C; CYCLOSPORINE-A;
D O I：
10.1016/0167-4889(91)90186-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protein kinase C activator phorbol 12-myristate 13-acetate (TPA) augments the level of cytoplasmic mRNA for cytoskeletal actin and the beta chain of the T cell antigen receptor (TCR-beta) in peripheral blood lymphocytes. Calcium ionophore A23187 has an antagonistic effect on these increases. The immunosuppressive drug cyclosporin A blocked both positive and negative effects of A23187 without affecting those of TPA. TPA-mediated increases in cytoplasmic corresponding total cellular RNA. Activation of protein kinase C can thus mediate the accumulation of these mRNAs by a post-transcriptional mechanism.
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页码：124 / 127
页数：4
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