POSTTRANSCRIPTIONAL REGULATION OF CYTOSKELETAL ACTIN AND LYMPHOCYTE-T RECEPTOR BETA-CHAIN MESSENGER-RNA BY PHORBOL ESTER

被引：6

作者：

GOODIER, MR ^{[1
]}

KAY, JE ^{[1
]}

机构：

[1] UNIV SUSSEX, SCH BIOL SCI, BIOCHEM LAB, BRIGHTON BN1 9RH, E SUSSEX, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1092卷 / 01期

关键词：

REGULATION; ACTIN; MESSENGER RNA; PHORBOL ESTER; T-CELL ANTIGEN RECEPTOR; PROTEIN KINASE-C; CYCLOSPORINE-A;

D O I：

10.1016/0167-4889(91)90186-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein kinase C activator phorbol 12-myristate 13-acetate (TPA) augments the level of cytoplasmic mRNA for cytoskeletal actin and the beta chain of the T cell antigen receptor (TCR-beta) in peripheral blood lymphocytes. Calcium ionophore A23187 has an antagonistic effect on these increases. The immunosuppressive drug cyclosporin A blocked both positive and negative effects of A23187 without affecting those of TPA. TPA-mediated increases in cytoplasmic corresponding total cellular RNA. Activation of protein kinase C can thus mediate the accumulation of these mRNAs by a post-transcriptional mechanism.

引用

页码：124 / 127

页数：4

共 50 条

[1] REGULATION OF IL-2-BETA RECEPTOR EXPRESSION AND BETA-CHAIN MESSENGER-RNA BY HUMAN THYMOCYTES
REEM, GH
HAN, X
MARCELLI, A
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1992, 87 (01): : 150 - 156
[2] GENERATION OF DIVERSITY OF THE BETA-CHAIN OF THE HUMAN LYMPHOCYTE-T RECEPTOR FOR ANTIGEN
LEIDEN, JM
STROMINGER, JL
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (12) : 4456 - 4460
[3] ESTRADIOL-17-BETA REGULATION OF OVINE FISH BETA-CHAIN MESSENGER-RNA INVIVO
ALEXANDER, DC
MILLER, WL
FEDERATION PROCEEDINGS, 1981, 40 (06) : 1574 - 1574
[4] REGULATION OF MESSENGER-RNA ABUNDANCE IN ACTIVATED LYMPHOCYTE-T - IDENTIFICATION OF MESSENGER-RNA SPECIES AFFECTED BY THE INHIBITION OF PROTEIN-SYNTHESIS
COLECLOUGH, C
KUHN, L
LEFKOVITS, I
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (05) : 1753 - 1757
[5] LACK OF GENE REARRANGEMENT AND MESSENGER-RNA EXPRESSION OF THE BETA-CHAIN OF THE T-CELL RECEPTOR IN SPONTANEOUS RAT LARGE GRANULAR LYMPHOCYTE LEUKEMIA LINES
REYNOLDS, CW
BONYHADI, M
HERBERMAN, RB
YOUNG, HA
HEDRICK, SM
JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (05): : 1249 - 1254
[6] ABSENCE OF GLOBIN MESSENGER-RNA (MESSENGER-RNA) FOR BETA-CHAIN AND GAMMA-CHAIN IN HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN (HPFH)
FORGET, BG
HILLMAN, DG
CASKEY, CT
SCHROEDER, WA
HUISMAN, THJ
BLOOD, 1975, 46 (06) : 1002 - 1002
[7] POSTTRANSCRIPTIONAL REGULATION OF TRANSFERRIN RECEPTOR MESSENGER-RNA BY IFN-GAMMA
BOURGEADE, MF
SILBERMANN, F
KUHN, L
TESTA, U
PESCHLE, C
MEMET, S
THANG, MN
BESANCON, F
NUCLEIC ACIDS RESEARCH, 1992, 20 (12) : 2997 - 3003
[8] REGULATION OF BETA-CHAIN MESSENGER-RNA OF OVINE FOLLICLE-STIMULATING-HORMONE BY 17 BETA-ESTRADIOL
MILLER, WL
ALEXANDER, DC
WU, JC
HUANG, ES
WHITFIELD, GK
HALL, SH
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1983, 53-4 (1-2) : 187 - 195
[9] A PHORBOL ESTER RESPONSE ELEMENT WITHIN THE HUMAN T-CELL RECEPTOR BETA-CHAIN ENHANCER
PROSSER, HM
WOTTON, D
GEGONNE, A
GHYSDAEL, J
WANG, SW
SPECK, NA
OWEN, MJ
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) : 9934 - 9938
[10] BETA-ADRENERGIC REGULATION OF BETA-ACTIN MESSENGER-RNA ABUNDANCE IN MOUSE PAROTID-GLANDS BY A POSTTRANSCRIPTIONAL MECHANISM
ROBERTS, SGE
COPE, GH
MCDONALD, CJ
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1991, 6 (01) : 79 - 86

← 1 2 3 4 5 →