DELTA-2-1,2,4-OXADIAZOLINES BY CONDENSATION OF AMIDOXIMES WITH KETONES AND ALDEHYDES

被引：17

作者：

LESSEL, J

机构：

[1] Institut Für Pharmazeutische, Universität Düsseldorf, Düsseldorf, W-4000

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 07期

关键词：

D O I：

10.1002/ardp.19933260703

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using acetic acid as a solvent, ketones and aromatic aldehydes react with amidoximes 1 to cyclic products, DELTA2-1,2,4-oxadiazolines 3. The lack of reactivity in neutral milieu is explained by MNDO calculations. Protonated carbonyl compounds are discussed to be the reactive species.

引用

页码：383 / 389

页数：7

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