AMPLIFICATION OF HUMAN APO(A) KRINGLE 4-37 FROM BLOOD LYMPHOCYTE DNA

被引：12
|
作者：
PFAFFINGER, D
MCLEAN, J
SCANU, AM
机构：
[1] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637
[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637
[3] UNIV CHICAGO,COMM GENET,CHICAGO,IL
[4] NOVOGENICS,REDWOOD CITY,CA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1225卷 / 01期
关键词：
APOLIPOPROTEIN(A); KRINGLE; 4-37; LYSINE BINDING POCKET; PCR;
D O I：
10.1016/0925-4439(93)90130-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have been able to amplify the lysine binding pocket region of human apo(a) kringle type 5 starting from the DNA isolated from peripheral blood lymphocytes. This development now permits the identification of Lp(a) mutants that by lacking their ability to bind to lysine/fibrin would have a lesser thrombogenic potential.
引用
收藏
页码：107 / 109
页数：3
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