REGULATION OF HEME-REGULATED EIF-2-ALPHA KINASE AND ITS EXPRESSION IN ERYTHROID-CELLS

被引：20
|
作者：
CHEN, JJ [1 ]
CROSBY, JS [1 ]
LONDON, IM [1 ]
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
BIOCHIMIE | 1994年 / 76卷 / 08期
关键词：
TRANSLATION; PROTEIN KINASE; HEME; ERYTHROID; INITIATION;
D O I：
10.1016/0300-9084(94)90080-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.
引用
收藏
页码：761 / 769
页数：9
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