REGULATION OF HEME-REGULATED EIF-2-ALPHA KINASE AND ITS EXPRESSION IN ERYTHROID-CELLS

被引：20
|
作者：
CHEN, JJ [1 ]
CROSBY, JS [1 ]
LONDON, IM [1 ]
机构：
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
来源：
BIOCHIMIE | 1994年 / 76卷 / 08期
关键词：
TRANSLATION; PROTEIN KINASE; HEME; ERYTHROID; INITIATION;
D O I：
10.1016/0300-9084(94)90080-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.
引用
收藏
页码：761 / 769
页数：9
相关论文
共 50 条
  • [21] Localization of the two heme binding domains of the heme-regulated eIF-2α kinase
    Rafie-Kolpin, M
    Chefalo, PJ
    Hussain, Z
    Hahn, J
    Chen, JJ
    FASEB JOURNAL, 1999, 13 (07): : A1566 - A1566
  • [22] EVIDENCE FOR THE ASSOCIATION OF THE HEME-REGULATED EIF-2-ALPHA KINASE WITH THE 90-KDA HEAT-SHOCK PROTEIN IN RABBIT RETICULOCYTE LYSATE INSITU
    MATTS, RL
    HURST, R
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (26) : 15542 - 15547
  • [23] Catalytic Activity of Heme-Regulated eIF2 Alpha Kinase (HRI) Regulates Fetal Hemoglobin
    Gupta, Dipti
    Hara, Yannis
    Lessard, Samuel
    Sturtevant, Sarah
    Nakamura, Yukio
    Krishnamoorthy, Sriram
    Demers, Melanie
    Hicks, Alexandra
    BLOOD, 2020, 136
  • [24] Translational control by heme-regulated eIF2a kinase during erythropoiesis
    Chen, Jane-Jane
    CURRENT OPINION IN HEMATOLOGY, 2014, 21 (03) : 172 - 178
  • [25] NO-induced activation mechanism of the heme-regulated eIF2α kinase
    Ishikawa, H
    Yun, BG
    Takahashi, S
    Hori, H
    Matts, RL
    Ishimori, K
    Morishima, I
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (46) : 13696 - 13697
  • [26] THE 90-KILODALTON PEPTIDE OF THE HEME-REGULATED EIF-2-ALPHA KINASE HAS SEQUENCE SIMILARITY WITH THE 90-KILODALTON HEAT-SHOCK PROTEIN
    ROSE, DW
    WETTENHALL, REH
    KUDLICKI, W
    KRAMER, G
    HARDESTY, B
    BIOCHEMISTRY, 1987, 26 (21) : 6583 - 6587
  • [27] Heme-regulated inhibitor: an overlooked eIF2α kinase in cancer investigations
    Azmi Yerlikaya
    Medical Oncology, 39
  • [28] Heme-regulated inhibitor: an overlooked eIF2α kinase in cancer investigations
    Yerlikaya, Azmi
    MEDICAL ONCOLOGY, 2022, 39 (05)
  • [29] No-induced activation mechanism of the heme-regulated eiF2α kinase
    Ishikawa, Haruto
    Yun, Bo-Geon
    Takahashi, Satoshi
    Hori, Hiroshi
    Matts, Robert L.
    Ishimori, Koichiro
    Morishima, Isao
    1600, American Chemical Society (124):
  • [30] Interdomain interactions regulate the activation of the heme-regulated eIF2α kinase
    Yun, BG
    Matts, JAB
    Matts, RL
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2005, 1725 (02): : 174 - 181
12345