TESTOSTERONE TREATMENT ENHANCES THROMBOXANE A(2) MIMETIC INDUCED CORONARY-ARTERY VASOCONSTRICTION IN GUINEA-PIGS

被引：52
|
作者：
SCHROR, K
MORINELLI, TA
MASUDA, A
MATSUDA, K
MATHUR, RS
HALUSHKA, PV
机构：
[1] MED UNIV S CAROLINA, DEPT PHARMACOL, DIV CLIN PHARMACOL, CHARLESTON, SC 29425 USA
[2] MED UNIV S CAROLINA, DEPT MED, DIV CLIN PHARMACOL, CHARLESTON, SC USA
[3] MED UNIV S CAROLINA, DEPT OBSTET & GYNECOL, CHARLESTON, SC 29425 USA
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 24卷
关键词：
LANGENDORFF PREPARATION; SEX STEROIDS; TESTOSTERONE; THROMBOXANE A(2) RECEPTORS; VASCULAR SMOOTH MUSCLE CELLS;
D O I：
10.1111/j.1365-2362.1994.tb02428.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thromboxane A(2) (TXA(2)) has been implicated as an important mediator of cardiovascular diseases. There have been several clinical reports of acute myocardial infarctions occurring in young male athletes abusing anabolic steroids. The effects of treatment of male Guinea pigs with testosterone on the responses to U46619, a TXA(2) receptor agonist, in the isolated perfused heart were determined. The maximum presser responses of the isolated perfused Guinea pig heart to U46619 were significantly (P<0.05) greater in the Guinea pigs treated with testosterone compared to the controls. These results indicate that testosterone can enhance coronary artery vascular reactivity to TXA(2).
引用
收藏
页码：50 / 52
页数：3
相关论文
共 50 条
  • [41] ANTIASTHMATIC ACTIVITY OF A NOVEL THROMBOXANE-A(2) ANTAGONIST, S-1452, IN GUINEA-PIGS
    ARIMURA, A
    ASANUMA, F
    KUROSAWA, A
    HARADA, M
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1992, 98 (03) : 239 - 246
  • [42] BRONCHOCONSTRICTION BY HISTAMINE AND BRADYKININ IN GUINEA-PIGS - RELATIONSHIP TO THROMBOXANE-A2 GENERATION AND THE EFFECT OF ASPIRIN
    ROSSONI, G
    OMINI, C
    VIGANO, T
    MANDELLI, V
    FOLCO, GC
    BERTI, F
    PROSTAGLANDINS, 1980, 20 (03): : 547 - 557
  • [43] THE THROMBOXANE-A2 MIMETIC U46619 WORSENS CANINE MYOCARDIAL HYPOPERFUSION DURING EXERCISE IN THE PRESENCE OF A CORONARY-ARTERY STENOSIS
    BACHE, RJ
    DAI, XZ
    CARDIOVASCULAR RESEARCH, 1992, 26 (04) : 351 - 356
  • [44] INHIBITION OF ENDOTHELIN-INDUCED BRONCHOCONSTRICTION BY OKY-046, A SELECTIVE THROMBOXANE-A2 SYNTHETASE INHIBITOR, IN GUINEA-PIGS
    NAMBU, F
    YUBE, N
    OMAWARI, N
    SAWADA, M
    OKEGAWA, T
    KAWASAKI, A
    IKEDA, S
    ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH, 1991, 21 : 453 - 456
  • [45] THROMBOXANE RELEASE IN CORONARY-ARTERY DISEASE - SPONTANEOUS VERSUS PACING-INDUCED ANGINA
    MEHTA, J
    MEHTA, P
    FELDMAN, RL
    HORALEK, C
    AMERICAN HEART JOURNAL, 1984, 107 (02) : 286 - 292
  • [46] CORONARY-ARTERY THROMBOSIS AND ELEVATED URINE IMMUNOREACTIVE THROMBOXANE-B2
    FOEGH, ML
    ELIASEN, K
    JOHANSEN, S
    HELFRICH, GB
    RAMWELL, PW
    PROSTAGLANDINS, 1986, 32 (05): : 781 - 788
  • [47] INHIBITORY EFFECT OF INHALATION OF A THROMBOXANE SYNTHETASE INHIBITOR ON BRONCHOCONSTRICTION INDUCED BY AEROSOLIZED LEUKOTRIENE-C4 AND THROMBOXANE-A2 ANALOG IN ANESTHETIZED GUINEA-PIGS
    FUJIMURA, M
    OGAWA, H
    SAITO, M
    SAKAMOTO, S
    MIYAKE, Y
    MATSUDA, T
    ALLERGY, 1991, 46 (07) : 534 - 539
  • [48] A NOVEL LOOP DIURETIC, TORASEMIDE, INHIBITS THROMBOXANE A2-INDUCED CONTRACTION IN THE ISOLATED CANINE CORONARY-ARTERY
    UCHIDA, T
    KIDO, H
    YAMANAGA, K
    OKITA, M
    WATANABE, M
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1992, 45 (02): : 121 - 124
  • [49] POSSIBLE ROLE OF THROMBOXANE-A2 IN VENTRICULAR ARRHYTHMIAS INDUCED BY CORONARY-ARTERY OCCLUSION AND REPERFUSION IN ANESTHETIZED DOGS
    OGURA, T
    SAITO, T
    TOKUTAKE, E
    HIBIYA, K
    WATANABE, I
    TAKAHASHI, N
    SAITO, S
    OZAWA, Y
    HATANO, M
    JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1984, 48 (08): : 878 - 878
  • [50] Involvement of thromboxane A(2) in antigen-induced nasal blockage in guinea pigs
    Yasui, K
    Asanuma, F
    Furue, Y
    Arimura, A
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 112 (04) : 400 - 405
12345