TESTOSTERONE TREATMENT ENHANCES THROMBOXANE A(2) MIMETIC INDUCED CORONARY-ARTERY VASOCONSTRICTION IN GUINEA-PIGS

被引：52
|
作者：
SCHROR, K
MORINELLI, TA
MASUDA, A
MATSUDA, K
MATHUR, RS
HALUSHKA, PV
机构：
[1] MED UNIV S CAROLINA, DEPT PHARMACOL, DIV CLIN PHARMACOL, CHARLESTON, SC 29425 USA
[2] MED UNIV S CAROLINA, DEPT MED, DIV CLIN PHARMACOL, CHARLESTON, SC USA
[3] MED UNIV S CAROLINA, DEPT OBSTET & GYNECOL, CHARLESTON, SC 29425 USA
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1994年 / 24卷
关键词：
LANGENDORFF PREPARATION; SEX STEROIDS; TESTOSTERONE; THROMBOXANE A(2) RECEPTORS; VASCULAR SMOOTH MUSCLE CELLS;
D O I：
10.1111/j.1365-2362.1994.tb02428.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Thromboxane A(2) (TXA(2)) has been implicated as an important mediator of cardiovascular diseases. There have been several clinical reports of acute myocardial infarctions occurring in young male athletes abusing anabolic steroids. The effects of treatment of male Guinea pigs with testosterone on the responses to U46619, a TXA(2) receptor agonist, in the isolated perfused heart were determined. The maximum presser responses of the isolated perfused Guinea pig heart to U46619 were significantly (P<0.05) greater in the Guinea pigs treated with testosterone compared to the controls. These results indicate that testosterone can enhance coronary artery vascular reactivity to TXA(2).
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页码：50 / 52
页数：3
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