Synthesis of some new piperazine-N,N'-bis-substituted derivatives as potential biologically active agents

In a search for new bactericidal and fungicidal agents some new piperazine-N,N'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, H-1 NMR, and mass spectral data. The antibacterial and antifungal activities of all prepared compounds have been determined using Gentamycin as standard antibiotic. Some compounds showed a high activity equivalent to that of the standard towards Escherichia coli, Serratia marcescens, Bacillus cereus, Staphylococcus aureus, and Candida albicans.