ASSESSMENT OF A SUPERPARAMAGNETIC IRON-OXIDE (AMI-25) AS A BRAIN CONTRAST AGENT

被引：41

作者：

KENT, TA

QUAST, MJ

KAPLAN, BJ

LIFSEY, RS

EISENBERG, HM

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT,GALVESTON,TX 77550

[2] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL,GALVESTON,TX 77550

[3] UNIV TEXAS,MED BRANCH,DIV NEUROSURG,GALVESTON,TX 77550

[4] UNIV TEXAS,MED BRANCH,INST MARINE BIOMED,GALVESTON,TX 77550

来源：

MAGNETIC RESONANCE IN MEDICINE | 1990年 / 13卷 / 03期

关键词：

D O I：

10.1002/mrm.1910130310

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have applied a superparamagnetic iron oxide formulation (AMI‐25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast‐enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：434 / 443

页数：10

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