GONADOTROPINS, ESTRADIOL, AND GROWTH-FACTORS REGULATE EPITHELIAL OVARIAN-CANCER CELL-GROWTH

被引：76

作者：

WIMALASENA, J ^{[1
]}

DOSTAL, R ^{[1
]}

MEEHAN, D ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PHYSIOL & BIOPHYS,OMAHA,NE 68105

来源：

GYNECOLOGIC ONCOLOGY | 1992年 / 46卷 / 03期

关键词：

D O I：

10.1016/0090-8258(92)90230-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Indirect evidence suggests that gonadal steroids and gonadotropins may have a role in the genesis of epithelial ovarian cancer. In the studies reported herein, we established 17β-estradiol (E2) secreting cell cultures from an omental metastasis of an epithelial ovarian cancer. We demonstrate that human chorionic gonadotropin (hCG), human follicle-stimulating hormone, and epidermal growth factor (EGF) increased cell growth in a dose- and time-dependent manner, whereas E2 inhibited cell growth in the nanomolar range. Epidermal growth factor was able to partially block the negative effect of E2; a similar but quantitatively lesser effect was observed with hCG. These results provide direct evidence to support the view that gonadotropins, EGF, TGFβ (transforming growth factor), and estradiol may modulate growth of metastatic epithelial ovarian cancer cells. © 1992.

引用

页码：345 / 350

页数：6

共 50 条

[21] EXPRESSION OF LEWIS-X ANTIGEN ON OVARIAN-CANCER CELLS IS RELATED TO CELL-GROWTH
JONES, LMH
GARDNER, MJ
TURNER, GA
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1994, 22 (02) : S99 - S99
[22] AUTOCRINE PARACRINE ROLES OF INSULIN-LIKE GROWTH-FACTORS IN PROSTATE-CANCER CELL-GROWTH
FUJITAYAMAGUCHI, Y
KASUYA, J
GIANNINI, S
KAWACHI, MH
KIMURA, G
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 229 - 229
[23] A NEW ASSAY SYSTEM FOR THE CELL-GROWTH PROMOTING EFFECTS OF INSULIN AND GROWTH-FACTORS
ZHANG, X
XIA, SL
TOMOOKA, Y
SAKAKURA, T
JING, NH
[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 1995, 27 (05) : 487 - 492
[24] EXTRACELLULAR ATP AUGMENTS MESANGIAL CELL-GROWTH INDUCED BY MULTIPLE GROWTH-FACTORS
SCHULZELOHOFF, E
SCHAGERL, S
OGILVIE, A
STERZEL, RB
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1995, 10 (11) : 2027 - 2034
[25] ROLE OF PDGF-LIKE GROWTH-FACTORS IN AUTOCRINE STIMULATION OF CELL-GROWTH
HELDIN, CH
HAMMACHER, A
BETSHOLTZ, C
WESTERMARK, B
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 2 - 2
[26] TUMOR PROMOTER SYNERGISTICALLY ENHANCES CELL-GROWTH WITH A VARIETY OF SERUM GROWTH-FACTORS
FRANTZ, CN
STILES, CD
SCHER, CD
[J]. PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1979, 20 (MAR): : 207 - 207
[27] ASCITIC FLUID FROM HUMAN OVARIAN-CANCER PATIENTS CONTAINS GROWTH-FACTORS NECESSARY FOR INTRAPERITONEAL GROWTH OF HUMAN OVARIAN ADENOCARCINOMA CELLS
MILLS, GB
MAY, C
HILL, M
CAMPBELL, S
SHAW, P
MARKS, A
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (03): : 851 - 855
[28] HEPARIN AFFINITY OF ANIONIC AND CATIONIC CAPILLARY ENDOTHELIAL CELL-GROWTH FACTORS - ANALYSIS OF HYPOTHALAMUS-DERIVED GROWTH-FACTORS AND FIBROBLAST GROWTH-FACTORS
KLAGSBRUN, M
SHING, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (03) : 805 - 809
[29] THE EFFECTS OF DIMETHYL-SULFOXIDE AND RETINOIC ACID ON THE CELL-GROWTH AND THE PHENOTYPE OF OVARIAN-CANCER CELLS
GRUNT, TW
SOMAY, C
PAVELKA, M
ELLINGER, A
DITTRICH, E
DITTRICH, C
[J]. JOURNAL OF CELL SCIENCE, 1991, 100 : 657 - 666
[30] REGULATION OF FOLLICLE DIFFERENTIATION BY GONADOTROPINS AND GROWTH-FACTORS
JOHNSON, AL
[J]. POULTRY SCIENCE, 1993, 72 (05) : 867 - 873

← 1 2 3 4 5 →