TRANSFORMATION OF POLYCYTHEMIA-VERA TO PH-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA

被引：25
|
作者：
HAQ, AU [1 ]
机构：
[1] VET ADM MED CTR,SHREVEPORT,LA
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 35卷 / 02期
关键词：
CML; Conversion; p; vera;
D O I：
10.1002/ajh.2830350209
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A patient with polycythemia vera (PV) developed chronic myelogenous leukemia (CML) 8 years after his initial presentation with erythrocytosis. The patient received a total of 3.5‐7 g of chlorambucil over an approximate period of 5 years. Transformation of PV to CML is very unusual; only three substantiated cases had been reported in literature until 1975, and none has been described since then. All patients received either 32P or chemotherapy for PV treatment, suggesting that irradiation and alkylating agents may have played a role in the transformation to CML. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：110 / 113
页数：4
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