A ONE-STEP SYNTHESIS OF [3-H-2]OXAZEPAM

被引：4
|
作者：
YANG, SK [1 ]
BAO, ZP [1 ]
SHOU, MG [1 ]
机构：
[1] NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1995年 / 36卷 / 09期
关键词：
OXAZEPAM; KETO-ENOL TAUTOMERISM; DEUTERIUM EXCHANGE; MASS SPECTROMETRY;
D O I：
10.1002/jlcr.2580360907
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The proton at 3-position of oxazepam (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1, 4-benzodiazepin-2-one) undergoes a deuterium exchange in deuterated alkaline methanol. A base-catalyzed keto-enol tautomerism is proposed to be responsible for the observed deuterium exchange. This simple method is a considerable improvement of the multi-step synthetic procedure reported in the literature.
引用
收藏
页码：861 / 869
页数：9
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