A ONE-STEP SYNTHESIS OF [3-H-2]OXAZEPAM

被引：4

作者：

YANG, SK ^{[1
]}

BAO, ZP ^{[1
]}

SHOU, MG ^{[1
]}

机构：

[1] NCI,MOLEC CARCINOGENESIS LAB,BETHESDA,MD 20892

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1995年 / 36卷 / 09期

关键词：

OXAZEPAM; KETO-ENOL TAUTOMERISM; DEUTERIUM EXCHANGE; MASS SPECTROMETRY;

D O I：

10.1002/jlcr.2580360907

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The proton at 3-position of oxazepam (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1, 4-benzodiazepin-2-one) undergoes a deuterium exchange in deuterated alkaline methanol. A base-catalyzed keto-enol tautomerism is proposed to be responsible for the observed deuterium exchange. This simple method is a considerable improvement of the multi-step synthetic procedure reported in the literature.

引用

页码：861 / 869

页数：9

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