HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .2. ISOLATION AND CHARACTERIZATION

被引：40
|
作者：
LEET, JE
SCHROEDER, DR
KRISHNAN, BS
MATSON, JA
机构：
[1] Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Connecticut 06492, 5 Research Parkway, P.O. Box 5100, Wallingford
来源：
JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期
关键词：
D O I：
10.7164/antibiotics.43.961
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码：961 / 966
页数：6
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