HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .2. ISOLATION AND CHARACTERIZATION

被引：40
|
作者：
LEET, JE
SCHROEDER, DR
KRISHNAN, BS
MATSON, JA
机构：
[1] Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Connecticut 06492, 5 Research Parkway, P.O. Box 5100, Wallingford
来源：
JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 08期
关键词：
D O I：
10.7164/antibiotics.43.961
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码：961 / 966
页数：6
相关论文
共 50 条
  • [1] INHIBITION OF ANTIBACTERIAL ACTIVITY OF HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS, BY FATTY-ACID SODIUM-SALTS
    MAMBER, SW
    BROOKSHIRE, KW
    DEAN, BJ
    FIRESTONE, RA
    LEET, JE
    MATSON, JA
    FORENZA, S
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (11) : 2633 - 2642
  • [2] THE ISOLATION OF A 2ND ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS
    MANN, RL
    BROMER, WW
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (11) : 2714 - 2716
  • [3] HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .1. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
    LAM, KS
    HESLER, GA
    MATTEI, JM
    MAMBER, SW
    FORENZA, S
    TOMITA, K
    JOURNAL OF ANTIBIOTICS, 1990, 43 (08): : 956 - 960
  • [4] Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus .3. Structural elucidation
    Leet, JE
    Schroeder, DR
    Golik, J
    Matson, JA
    Doyle, TW
    Lam, KS
    Hill, SE
    Lee, MS
    Whitney, JL
    Krishnan, BS
    JOURNAL OF ANTIBIOTICS, 1996, 49 (03): : 299 - 311
  • [5] CARRIOMYCIN, A NEW POLYETHER ANTIBIOTIC PRODUCED BY STREPTOMYCES-HYGROSCOPICUS
    IMADA, A
    NOZAKI, Y
    HASEGAWA, T
    MIZUTA, E
    IGARASI, S
    YONEDA, M
    JOURNAL OF ANTIBIOTICS, 1978, 31 (01): : 7 - 14
  • [6] FLAMBAMYCIN, A NEW ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS DS 23 230
    NINET, L
    BENAZET, F
    CHARPENTIE, Y
    DUBOST, M
    FLORENT, J
    LUNEL, J
    MANCY, D
    PREUDHOM.J
    EXPERIENTIA, 1974, 30 (11): : 1270 - 1272
  • [7] THE REGULATION OF ANTIBIOTIC BIOSYNTHESIS IN STREPTOMYCES-HYGROSCOPICUS
    HOLT, T
    RAIBAUD, A
    LAURENTWINTER, C
    MURAKAMI, T
    DAVIES, J
    THOMPSON, C
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 132 - MBTD
  • [8] EMERICID - NEW POLYETHER ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS (DS 24 367)
    NINET, L
    BENAZET, F
    DEPAIRE, H
    FLORENT, J
    LUNEL, J
    MANCY, D
    ABRAHAM, A
    CARTIER, JR
    CHEZELLES, ND
    GODARD, C
    MOREAU, M
    TISSIER, R
    LALLEMAND, JY
    EXPERIENTIA, 1976, 32 (03): : 319 - 321
  • [9] DESCRIPTION AND ANTIBIOTIC PRODUCTION OF STREPTOMYCES-HYGROSCOPICUS VAR GELDANUS
    DEBOER, C
    DIETZ, A
    JOURNAL OF ANTIBIOTICS, 1976, 29 (11): : 1182 - 1188
  • [10] ISOLATION OF NEOCOPIAMYCIN A FROM STREPTOMYCES-HYGROSCOPICUS VAR CRYSTALLOGENES, THE COPIAMYCIN SOURCE
    ARAI, T
    UNO, J
    HORIMI, I
    FUKUSHIMA, K
    JOURNAL OF ANTIBIOTICS, 1984, 37 (02): : 103 - 109
12345