MODIFIED OLIGONUCLEOTIDES .4. SOLID-PHASE SYNTHESIS AND PRELIMINARY EVALUATION OF PHOSPHOROTHIOATE RNA AS POTENTIAL ANTISENSE AGENTS

被引：15
|
作者：
MORVAN, F [1 ]
RAYNER, B [1 ]
IMBACH, JL [1 ]
机构：
[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,UA 488,CASE 008,PL E BATAILLON,F-34095 MONTPELLIER 5,FRANCE
来源：
TETRAHEDRON LETTERS | 1990年 / 31卷 / 49期
关键词：
D O I：
10.1016/S0040-4039(00)97264-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
For the first time a phosphorothioate oligoribonucleotide, namely PS-C14, has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC14 and binds to complementary RNA strands. © 1990.
引用
收藏
页码：7149 / 7152
页数：4
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