MODIFIED OLIGONUCLEOTIDES .4. SOLID-PHASE SYNTHESIS AND PRELIMINARY EVALUATION OF PHOSPHOROTHIOATE RNA AS POTENTIAL ANTISENSE AGENTS

被引：15

作者：

MORVAN, F ^{[1
]}

RAYNER, B ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,UA 488,CASE 008,PL E BATAILLON,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)97264-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the first time a phosphorothioate oligoribonucleotide, namely PS-C14, has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC14 and binds to complementary RNA strands. © 1990.

引用

页码：7149 / 7152

页数：4

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