SCALE-UP OF PREPARATIVE LIQUID-CHROMATOGRAPHY FOR PURIFICATION OF MACROLIDE ANTIBIOTICS

被引：2
|
作者：
KAWAI, T
EGASHIRA, R
ITSUKI, H
KAWASAKI, J
机构：
[1] Dept. of Chem. Eng., Tokyo Inst. of Tech., Tokyo
来源：
KAGAKU KOGAKU RONBUNSHU | 1993年 / 19卷 / 04期
关键词：
PREPARATIVE LIQUID CHROMATOGRAPHY; CHROMATOGRAM SIMULATION; SCALE UP; MACROLIDE ANTIBIOTICS; ERYTHROMYCIN;
D O I：
10.1252/kakoronbunshu.19.680
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
A method was proposed for measuring the parameters of the adsorption isotherm and mass-transfer coefficients using an analytical column in order to simulate chromatograms of preparative liquid chromatography (prep LC). Close agreement between measured and simulated chromatograms was obtained for prep LC purification of erythromycin. The results showed that this method can be fully applied for scale-up from analytical LC to prep LC.
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页码：680 / 683
页数：4
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