SCALE-UP OF PREPARATIVE LIQUID-CHROMATOGRAPHY FOR PURIFICATION OF MACROLIDE ANTIBIOTICS

被引：2
|
作者：
KAWAI, T
EGASHIRA, R
ITSUKI, H
KAWASAKI, J
机构：
[1] Dept. of Chem. Eng., Tokyo Inst. of Tech., Tokyo
来源：
KAGAKU KOGAKU RONBUNSHU | 1993年 / 19卷 / 04期
关键词：
PREPARATIVE LIQUID CHROMATOGRAPHY; CHROMATOGRAM SIMULATION; SCALE UP; MACROLIDE ANTIBIOTICS; ERYTHROMYCIN;
D O I：
10.1252/kakoronbunshu.19.680
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
A method was proposed for measuring the parameters of the adsorption isotherm and mass-transfer coefficients using an analytical column in order to simulate chromatograms of preparative liquid chromatography (prep LC). Close agreement between measured and simulated chromatograms was obtained for prep LC purification of erythromycin. The results showed that this method can be fully applied for scale-up from analytical LC to prep LC.
引用
收藏
页码：680 / 683
页数：4
相关论文
共 50 条
  • [31] RECYCLE IN PREPARATIVE LIQUID-CHROMATOGRAPHY
    CONROE, KE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1974, : 84 - 84
  • [32] Evaluation of scale-up from analytical to preparative supercritical fluid chromatography
    Enmark, Martin
    Asberg, Dennis
    Leek, Hanna
    Ohlen, Kristina
    Klarqvist, Magnus
    Samuelsson, Jorgen
    Fornstedt, Torgny
    JOURNAL OF CHROMATOGRAPHY A, 2015, 1425 : 280 - 286
  • [33] PREPARATIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE PURIFICATION OF NATURAL ANTHOCYANINS
    FIORINI, M
    JOURNAL OF CHROMATOGRAPHY A, 1995, 692 (1-2) : 213 - 219
  • [34] ISOLATION AND PURIFICATION OF LECITHIN BY PREPARATIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    AMARI, JV
    BROWN, PR
    GRILL, CM
    TURCOTTE, JG
    JOURNAL OF CHROMATOGRAPHY, 1990, 517 : 219 - 228
  • [35] Orthogonal analytical screening for liquid chromatography-mass spectrometry method development and preparative scale-up
    Font, Luis M.
    Fontana, A.
    Galceran, M. T.
    Iturrino, L.
    Perez, V.
    JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (01) : 74 - 82
  • [36] Determination of macrolide antibiotics by liquid chromatography
    Leal, C
    Codony, R
    Compañó, R
    Granados, M
    Prat, MD
    JOURNAL OF CHROMATOGRAPHY A, 2001, 910 (02) : 285 - 290
  • [37] CHARACTERIZATION OF AROMATIC HEPTANE MACROLIDE ANTIBIOTICS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    MECHLINSKI, W
    SCHAFFNER, CP
    JOURNAL OF ANTIBIOTICS, 1980, 33 (06): : 591 - 599
  • [38] FAST LIQUID CHROMATOGRAPHY OF MACROLIDE ANTIBIOTICS
    OMURA, S
    SUZUKI, Y
    NAKAGAWA, A
    HATA, T
    JOURNAL OF ANTIBIOTICS, 1973, 26 (12): : 794 - 796
  • [39] Analysis of macrolide antibiotics by liquid chromatography
    de la Huebra, MJG
    Vincent, U
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 39 (3-4) : 376 - 398
  • [40] Scale-up purification for rutin hyrdrolysates by high-performance counter-current chromatography coupled with semi-preparative high-performance liquid chromatography
    Chen, Jinying
    He, Linhong
    Yang, Tao
    SEPARATION SCIENCE AND TECHNOLOGY, 2016, 51 (09) : 1523 - 1530
12345