ACTIVATION OF RAT GLUTATHIONE TRANSFERASES IN CLASS-MU BY ACTIVE OXYGEN SPECIES

被引：33
|
作者：
MURATA, T [1 ]
HATAYAMA, I [1 ]
SATOH, K [1 ]
TSUCHIDA, S [1 ]
SATO, K [1 ]
机构：
[1] HIROSAKI UNIV, SCH MED, DEPT BIOCHEM 2, 5 ZAIFU-CHO, HIROSAKI, AOMORI 036, JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)91223-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The activities of rat glutathione transferases (GSTs) 3-3, 3-4, 4-4 in Class mu towards 1-chloro-2,4-dinitrobenzene (CDNB) but not 1,2-dichloro-4-nitrobenzene were increased up to 5-fold during preincubation with 0.4 mM xanthine and xanthine oxidase in 50 mM potassium phosphate, pH 7.8, containing 0.1 mM EDTA. The activated GST 3-4, purified by S-hexylglutathione affinity chromatography after the treatment, had a higher specific activity (130 units/mg) than that of the nontreated (35 units/mg), the Km and Vmax values for glutathione or CDNB also were increased. Other rat GSTs in Class alpha and pi were inactivated by the same treatment. In the presence of superoxide dismutase, the activation of GST 3-4 did not occur. © 1990.
引用
收藏
页码：845 / 851
页数：7
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