ACTIVATION OF RAT GLUTATHIONE TRANSFERASES IN CLASS-MU BY ACTIVE OXYGEN SPECIES

被引：33

作者：

MURATA, T ^{[1
]}

HATAYAMA, I ^{[1
]}

SATOH, K ^{[1
]}

TSUCHIDA, S ^{[1
]}

SATO, K ^{[1
]}

机构：

[1] HIROSAKI UNIV, SCH MED, DEPT BIOCHEM 2, 5 ZAIFU-CHO, HIROSAKI, AOMORI 036, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)91223-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activities of rat glutathione transferases (GSTs) 3-3, 3-4, 4-4 in Class mu towards 1-chloro-2,4-dinitrobenzene (CDNB) but not 1,2-dichloro-4-nitrobenzene were increased up to 5-fold during preincubation with 0.4 mM xanthine and xanthine oxidase in 50 mM potassium phosphate, pH 7.8, containing 0.1 mM EDTA. The activated GST 3-4, purified by S-hexylglutathione affinity chromatography after the treatment, had a higher specific activity (130 units/mg) than that of the nontreated (35 units/mg), the Km and Vmax values for glutathione or CDNB also were increased. Other rat GSTs in Class alpha and pi were inactivated by the same treatment. In the presence of superoxide dismutase, the activation of GST 3-4 did not occur. © 1990.

引用

页码：845 / 851

页数：7

共 50 条

[21] DENITROSATION OF 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA BY CLASS-MU GLUTATHIONE TRANSFERASES AND ITS ROLE IN CELLULAR-RESISTANCE IN RAT-BRAIN TUMOR-CELLS
SMITH, MT
EVANS, CG
DOANESETZER, P
CASTRO, VM
TAHIR, MK
MANNERVIK, B
CANCER RESEARCH, 1989, 49 (10) : 2621 - 2625
[22] Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling
Hansson, LO
Bolton-Grob, R
Massoud, T
Mannervik, B
JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (02) : 265 - 276
[23] The enhanced affinity for thiolate anion and activation of enzyme-bound glutathione is governed by an arginine residue of human Mu class glutathione S-transferases
Patskovsky, YV
Patskovska, LN
Listowsky, I
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) : 3296 - 3304
[24] THETA, A NEW CLASS OF GLUTATHIONE TRANSFERASES PURIFIED FROM RAT AND MAN
MEYER, DJ
COLES, B
PEMBLE, SE
GILMORE, KS
FRASER, GM
KETTERER, B
BIOCHEMICAL JOURNAL, 1991, 274 : 409 - 414
[25] Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs
Eklund, Birgitta I.
Mannervik, Bengt
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2007, 1770 (08): : 1098 - 1103
[26] HALOTHANE - INHIBITION AND ACTIVATION OF RAT HEPATIC GLUTATHIONE S-TRANSFERASES
IVANETICH, KM
THUMSER, AEA
HARRISON, GG
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (10) : 1903 - 1908
[27] Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
Bogaards, JJP
Venekamp, JC
Salmon, FGC
van Bladeren, PJ
CHEMICO-BIOLOGICAL INTERACTIONS, 1999, 117 (01) : 1 - 14
[28] Regio- and enantioselectivities in epoxide conjugations are modulated by residue 210 in Mu class glutathione transferases
Ivarsson, Y
Mannervik, B
PROTEIN ENGINEERING DESIGN & SELECTION, 2005, 18 (12): : 607 - 616
[29] ISOENZYME(S) OF GLUTATHIONE TRANSFERASE (CLASS-MU) AS A MARKER FOR THE SUSCEPTIBILITY TO LUNG-CANCER - A FOLLOW-UP-STUDY
SEIDEGARD, J
PERO, RW
MARKOWITZ, MM
ROUSH, G
MILLER, DG
BEATTIE, EJ
CARCINOGENESIS, 1990, 11 (01) : 33 - 36
[30] Heterologous expression and functional characterization of avian mu-class glutathione S-transferases
Bunderson, Brett R.
Kim, Ji Eun
Croasdell, Amanda
Mendoza, Kristelle M.
Reed, Kent M.
Coulombe, Roger A., Jr.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2013, 158 (02): : 109 - 116

← 1 2 3 4 5 →