Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

被引：3
|
作者：
Mamriev, Dana [1 ]
Larisch, Sarit [1 ]
机构：
[1] Univ Haifa, Dept Biol, Cell Death & Canc Res Lab, IL-31905 Haifa, Israel
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 04期
关键词：
Apoptosis; Mitochondria; Bcl-2; XIAP; Caspases; Ubiquitin; Protein degradation; E3-ligase;
D O I：
10.1080/23723556.2018.1441630
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation
    Kim, YH
    Park, JW
    Lee, JY
    Surh, YJ
    Kwon, TK
    BIOCHEMICAL PHARMACOLOGY, 2003, 66 (09) : 1779 - 1786
  • [32] Another One Bites the Dust: Recent Initiatives in Correctional Reform in New Zealand
    Newbold, Greg
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF CRIMINOLOGY, 2008, 41 (03): : 384 - 401
  • [33] Expression of caspase 8, bcl-2, survivin and XIAP in Wilms' tumors
    Condron, M. R.
    Miller, M.
    Brown, R. E.
    LABORATORY INVESTIGATION, 2008, 88 : 332A - 332A
  • [34] Expression of caspase 8, bcl-2, survivin and XIAP in Wilms' tumors
    Galli, S.
    Tsokos, M.
    Prygodzki, R.
    Ahmed, A.
    MODERN PATHOLOGY, 2008, 21 : 332A - 332A
  • [35] Expression of caspase 8, bcl-2, survivin and XIAP in Wilms' tumors
    Galli, S.
    Tsokos, M.
    Przygodzki, R.
    Ahmed, A.
    LABORATORY INVESTIGATION, 2008, 88 : 332A - 332A
  • [36] VKORC1 gene variation and venous thrombosis:: 'another one bites the dust'?
    Reitsma, P. H.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (10) : 2017 - 2019
  • [37] Acute Onset Hyperammonemic Encephalopathy Related to Fibrolamellar Carcinoma: Another One Bites the Dust
    Surjan, Rodrigo C. T.
    Silveira, Sergio P.
    Pinheiro, Joao Lucas S.
    Pinheiro, Pedro Henrique S.
    Barros, Mauricio F. A.
    Soares, Silvia Regina P.
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2020, 359 (04): : 242 - 244
  • [38] Another one bites the dust - Two street canyons studied with magnetic biomonitoring and OSPM modelling
    Limo, Jukka
    Kauhaniemi, Mari
    Paturi, Petriina
    Keskinen, Jukka-Pekka
    Karppinen, Ari
    Makinen, Joni
    ATMOSPHERIC ENVIRONMENT, 2024, 319
  • [39] Another One Bites the Dust Pulsed Field Ablation of Posterior Wall Fails to Provide Benefit
    Parkash, Ratika
    Gerstenfeld, Edward P.
    JACC-CLINICAL ELECTROPHYSIOLOGY, 2024, 10 (05) : 913 - 915
  • [40] Use of Hydrocortisone Based on Plasma Biomarkers in Patients with Septic Shock: Another One Bites the Dust?
    Moller, Morten Hylander
    Shankar-Hari, Manu
    Alhazzani, Waleed
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (05) : 644 - 646
12345