Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

被引：3
|
作者：
Mamriev, Dana [1 ]
Larisch, Sarit [1 ]
机构：
[1] Univ Haifa, Dept Biol, Cell Death & Canc Res Lab, IL-31905 Haifa, Israel
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 04期
关键词：
Apoptosis; Mitochondria; Bcl-2; XIAP; Caspases; Ubiquitin; Protein degradation; E3-ligase;
D O I：
10.1080/23723556.2018.1441630
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.
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