Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

被引：3

作者：

Mamriev, Dana ^{[1
]}

Larisch, Sarit ^{[1
]}

机构：

[1] Univ Haifa, Dept Biol, Cell Death & Canc Res Lab, IL-31905 Haifa, Israel

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 04期

关键词：

Apoptosis; Mitochondria; Bcl-2; XIAP; Caspases; Ubiquitin; Protein degradation; E3-ligase;

D O I：

10.1080/23723556.2018.1441630

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.

引用

页数：2

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