ACCELERATION OF DIABETES IN YOUNG NOD MICE WITH A CD4+ ISLET-SPECIFIC T-CELL CLONE

被引：368
|
作者：
HASKINS, K
MCDUFFIE, M
机构：
[1] Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver
来源：
SCIENCE | 1990年 / 249卷 / 4975期
关键词：
D O I：
10.1126/science.2205920
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4+ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.
引用
收藏
页码：1433 / 1436
页数：4
相关论文
共 50 条
  • [31] β-islet cell specific CD4+ T cell responses in patients with type 1 diabetes mellitus and healthy controls
    Olson, JA
    Parry, SL
    Herman, A
    Erlich, H
    Noble, J
    Wilson, D
    Sonderstrup, G
    [J]. DIABETES, 1999, 48 : A433 - A433
  • [32] Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein:: A novel β cell autoantigen in type 1 diabetes
    Mukherjee, R
    Wagar, D
    Stephens, TA
    Lee-Chan, E
    Singh, B
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (09): : 5306 - 5315
  • [33] CD4+ CYTOLYTIC T-CELL CLONE CONFERS PROTECTION AGAINST MURINE MALARIA
    TSUJI, M
    ROMERO, P
    NUSSENZWEIG, RS
    ZAVALA, F
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05): : 1353 - 1357
  • [34] Cellular and molecular mechanisms for the prevention of spontaneous autoimmune diabetes and recurrent diabetes in syngeneic-islet transplanted NOD mice by a new type of CD4+ T cell.
    Han, HS
    Jun, HS
    Utsugi, T
    Kawazu, S
    Yoon, JW
    [J]. DIABETES, 1996, 45 : 79 - 79
  • [35] CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice
    Yoneda, R
    Yokono, K
    Nagata, M
    Tominaga, Y
    Moriyama, H
    Tsukamoto, K
    Miki, M
    Okamoto, N
    Yasuda, H
    Amano, K
    Kasuga, M
    [J]. DIABETOLOGIA, 1997, 40 (09) : 1044 - 1052
  • [36] CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice
    R. Yoneda
    K. Yokono
    M. Nagata
    Y. Tominaga
    H. Moriyama
    K. Tsukamoto
    M. Miki
    N. Okamoto
    H. Yasuda
    K. Amano
    M. Kasuga
    [J]. Diabetologia, 1997, 40 : 1044 - 1052
  • [37] A CD8 T-CELL CLONE DERIVED FROM NOD ISLETS CAN CAUSE DIABETES IN THE ABSENCE OF CD4 T-CELLS
    WONG, S
    WEN, LI
    VISINTIN, I
    FLAVELL, RA
    JANEWAY, CA
    [J]. DIABETES, 1995, 44 : A51 - A51
  • [38] CD4+ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice.
    Burrack, A.
    Beard, K.
    Coulombe, M.
    Gill, R.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 : 351 - 351
  • [39] THE CONTACT SENSITIVITY (CS) INDUCING EFFECTOR T-CELL CLONE BELONGS TO A NEW MURINE CD4+ T-CELL SUBSET
    YOKOZEKI, H
    KATAYAMA, I
    NISHIOKA, K
    [J]. CLINICAL RESEARCH, 1990, 38 (02): : A621 - A621
  • [40] HUMAN CD8+ T-CELL CLONE REGULATES AUTOLOGOUS CD4+ MYELIN BASIC-PROTEIN SPECIFIC T-CELLS
    CHOU, YK
    HENDERIKX, P
    JONES, RE
    KOTZIN, B
    HASHIM, GA
    OFFNER, H
    VANDENBARK, AA
    [J]. AUTOIMMUNITY, 1992, 14 (02) : 111 - 119
12345