ACCELERATION OF DIABETES IN YOUNG NOD MICE WITH A CD4+ ISLET-SPECIFIC T-CELL CLONE

被引：368
|
作者：
HASKINS, K
MCDUFFIE, M
机构：
[1] Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver
来源：
SCIENCE | 1990年 / 249卷 / 4975期
关键词：
D O I：
10.1126/science.2205920
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4+ islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.
引用
收藏
页码：1433 / 1436
页数：4
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