STRUCTURE-ACTIVITY-RELATIONSHIPS FOR RELAXATION OF SMOOTH-MUSCLE BY VIP

被引：3
|
作者：
SHIRAHASE, H
COY, DH
RORSTAD, OP
机构：
[1] UNIV CALGARY,CALGARY GEN HOSP,DEPT MED,841 CTR AVE E,CALGARY T2E 0A1,AB,CANADA
[2] TULANE UNIV,MED CTR,PEPTIDE RES LAB,NEW ORLEANS,LA 70112
来源：
PEPTIDES | 1994年 / 15卷 / 02期
关键词：
VIP; RECEPTOR; VASCULATURE; SMOOTH MUSCLE;
D O I：
10.1016/0196-9781(94)90026-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Utilizing VIP and five VIP analogues, concentration-response curves for relaxation of rat mesenteric artery and rat gastric longitudinal muscle were determined for comparison with our previously published radioligand binding data on rat smooth muscle and other tissues. The biological potency of the VIP analogues in the present study compared more closely with their potency for VIP receptor binding in smooth muscle tissue (arteries) vs. other tissues (pituitary, brain, liver).
引用
收藏
页码：383 / 385
页数：3
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