STRUCTURE-ACTIVITY-RELATIONSHIPS FOR RELAXATION OF SMOOTH-MUSCLE BY VIP

被引：3
|
作者：
SHIRAHASE, H
COY, DH
RORSTAD, OP
机构：
[1] UNIV CALGARY,CALGARY GEN HOSP,DEPT MED,841 CTR AVE E,CALGARY T2E 0A1,AB,CANADA
[2] TULANE UNIV,MED CTR,PEPTIDE RES LAB,NEW ORLEANS,LA 70112
来源：
PEPTIDES | 1994年 / 15卷 / 02期
关键词：
VIP; RECEPTOR; VASCULATURE; SMOOTH MUSCLE;
D O I：
10.1016/0196-9781(94)90026-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Utilizing VIP and five VIP analogues, concentration-response curves for relaxation of rat mesenteric artery and rat gastric longitudinal muscle were determined for comparison with our previously published radioligand binding data on rat smooth muscle and other tissues. The biological potency of the VIP analogues in the present study compared more closely with their potency for VIP receptor binding in smooth muscle tissue (arteries) vs. other tissues (pituitary, brain, liver).
引用
收藏
页码：383 / 385
页数：3
相关论文
共 50 条
  • [21] STRUCTURE-ACTIVITY-RELATIONSHIPS
    FERSHT, AR
    PROTEIN ENGINEERING, 1987, 1 (03): : 233 - 233
  • [22] STRUCTURE-ACTIVITY-RELATIONSHIPS
    ARCOS, JC
    ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1987, 21 (08) : 743 - 745
  • [23] RELAXATION OF THE SMOOTH-MUSCLE OF THE RAT TAIL ARTERY ASSOCIATED WITH HYPERPOLARIZATION OF THE SMOOTH-MUSCLE
    KOTECHA, N
    NEILD, TO
    JOURNAL OF PHYSIOLOGY-LONDON, 1986, 371 : P261 - P261
  • [24] POTASSIUM CHANNEL OPENERS - EVALUATION OF PINACIDIL STRUCTURE-ACTIVITY-RELATIONSHIPS IN SMOOTH AND CARDIAC-MUSCLE PREPARATIONS
    ROBERTSON, DW
    BEEDLE, EE
    ERTEL, PJ
    ZIMMERMAN, K
    STEINBERG, MI
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 126 - MEDI
  • [25] THE MODULATORY FUNCTION OF GALANIN - POTENTIATION OF VIP-INDUCED RELAXATION IN ISOLATED SMOOTH-MUSCLE CELLS
    GRIDER, JR
    MAKHLOUF, GM
    GASTROENTEROLOGY, 1988, 94 (05) : A157 - A157
  • [26] STRUCTURE-FUNCTION-RELATIONSHIPS IN SMOOTH-MUSCLE - THE MISSING LINKS
    SMALL, JV
    BIOESSAYS, 1995, 17 (09) : 785 - 792
  • [27] MECHANISM OF SMOOTH-MUSCLE RELAXATION BY ROCIVERINE
    DAGOSTINO, G
    ZONTA, F
    BARBONE, MGS
    GRANA, E
    BRUNORI, P
    SUBISSI, A
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 1984, 34-1 (05): : 584 - 589
  • [28] AMILORIDE RELAXATION OF THE ARTERIAL SMOOTH-MUSCLE
    FURTADO, MR
    SILVA, EG
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1986, 19 (4-5) : A578 - A578
  • [29] VIP AND ACETYLCHOLINE - NEUROTRANSMITTERS IN ESOPHAGEAL CIRCULAR SMOOTH-MUSCLE
    BEHAR, J
    GUENARD, V
    WALSH, JH
    BIANCANI, P
    AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (03): : G380 - G385
  • [30] HETEROGENEITY IN RELAXATION OF VASCULAR SMOOTH-MUSCLE
    TODA, N
    BLOOD VESSELS, 1977, 14 (04): : 246 - 247
12345