(8A-ALPHA,12A-ALPHA,13A-ALPHA)-5,8,8A,9,10,11,12,12A,13,13A-DECAHYDRO-3-METHOXY-12-(METHYLSULFONYL)-6H-ISOQUINO[2,1-G][1,6]NAPHTHYRIDINE, A POTENT AND HIGHLY SELECTIVE ALPHA2-ADRENOCEPTOR ANTAGONIST

被引：40

作者：

CLARK, RD ^{[1
]}

REPKE, DB ^{[1
]}

KILPATRICK, AT ^{[1
]}

BROWN, CM ^{[1
]}

MACKINNON, AC ^{[1
]}

CLAGUE, RU ^{[1
]}

SPEDDING, M ^{[1
]}

机构：

[1] SYNTEX RES CTR,DEPT PHARMACOL,EDINBURGH EH14 4AP,SCOTLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 09期

关键词：

D O I：

10.1021/jm00129a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2034 / 2036

页数：3

共 35 条

[21] SIMPLE SYNTHESIS OF 8-(TRIFLUOROMETHYL)-2,3,5,6,11,12,14,15-OCTAHYDRO-1H,4H,10H,13H-DIQUINOLIZINO[9,9A,1-BC=9',9A',1-HI]XANTHYLIUM PERCHLORATE, AN EFFICIENT DYE-LASER
HALEY, NF
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1977, 14 (04) : 683 - 683
[22] Crystal structure of (1R*,2S*,3R*,4R*)-ethyl 3-acetoxy-1,2,3,4,5,6,7,8,9,10,11,12,13,14-tetradecahydro-1,4-epoxybenzo-cyclodecene-2-carboxylate, C10H20[C6H4O](COOC2H5)(OCOCH3)
Peters, K
Peters, EM
Taugerbeck, A
Tochtermann, W
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 1999, 214 (01): : 99 - 100
[23] Crystal structure of (1R*,2S*,3S*,4R*)-3-bromo-1,2,3,4,5,6,7,8,9,10,11,12,13,14-tetradecahydro-1,4-epoxy-benzocyclododecene-2-carboxylic acid, C6H4O(CH2)10BrCOOH
Peters, K
Peters, EM
Taugerbeck, A
Tochtermann, W
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 1998, 213 (03): : 497 - 498
[24] ON THE SHORT C-C BOND LENGTHS IN MACROCYCLIC LIGAND SYSTEMS INCORPORATING ETHER DONORS - A COMPARATIVE NEUTRON AND X-RAY-DIFFRACTION STUDY OF AN O2N3 DONOR MACROCYCLE - 6,7,8,9,10,11,12,13,19,20-DECAHYDRO-5H-DIBENZO[E,P][1,4,8,11,14]DIOXATRIAZACYCLOHEPTADECINE
ADAM, KR
DAVIS, RL
KENNARD, CLH
CALOS, NJ
LINDOY, LF
MCCOOL, BJ
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (24) : 1784 - 1785
[25] THE X-RAY MOLECULAR-STRUCTURES OF METHYL 4,5,7,8,9,10,11,12,13,14-DECAHYDRO-7,9-DIOXO-8,15-METHENOPYRROLO[3,2,1-OP][1]BENZAZACYCLODODECINE-16-CARBOXYLATE, METHYL (Z)-1',2',4',5'-TETRAHYDRO-2,4'-DIOXOSPIRO(CYCLOHEPTANE-1,6'-[6H]PYRROLO[3,2,1-IJ]QUINOLIN)-5'-YLIDENEACETATE, AND METHYL (Z)-1,1A,2,3,4,8,9,9A-OCTAHYDRO-1-METHOXYCARBONYLMETHYL-11-METHOXYCARBONYLMETHYLENE-12-OXO-1B,4A-EPOXYETHANOINDOLIZINO[2,3,4,5,6-JKLM]CARBAZOLE-1-CARBOXYLATT
LETCHER, RM
LAI, TF
MAK, TCW
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (09): : 1921 - 1926
[26] Crystal structure of 3-hydroxy-3-methoxy-1-methyl-8-phenyl-9,13-epoxyhexacyclo[6.5.1.0(2,7).0(4,12).0(5,10).0(9,13)]tetradecan-6-one, C22H22O4
Peters, K
Peters, EM
vonSchnering, HG
Griesbeck, AG
Deufel, T
ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1996, 211 (06): : 435 - 436
[27] 17-(5-Ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol from Chisocheton tomentosus (Meliaceae)
Najmuldeen, Ibrahim A.
Hadi, Abdul Hamid Abdul
Awang, Khalijah
Mohamad, Khalit
Ng, Seik Weng
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O2163 - U2375
[28] (5S)-5-[(4aR,8aS,9E,11S,13R,14S,16R,17R,19S)-11,19-Dihydroxy-8,10,13,16-tetramethyl-18-methylidene-3,4,5,6,8a,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-2H-14,17-epoxybenzo[2,3]cyclohexadeca[1,2-b]pyridine-7-yl]-3-methylfuran-2(5H)-one (12-Methylgymnodimine B)
Strangman, Wendy
Anttila, Matthew
Tomas, Carmelo
Wright, Jeffrey L. C.
MOLBANK, 2016, (02)
[29] Crystal structure of (Z)-N-(17-(1-(dimethylamino)ethyl)-10,13-dimethyl-4-oxo-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta-[a]phenanthren-3-yl)-3-methylbut-2-enimidic acid dichloromethane monosolvate, C29H45Cl2N2O2
He, Kang
Zou, Juan
Wang, Jin Xi
Du, Jiang
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2013, 228 (03): : 327 - 328
[30] THE STRUCTURE OF TRICARBONYL(C,13,14,C-ETA-(2RS,5SR,8SR,13RS,14SR)-8-METHYL-13,14-DIMETHYLENE-9-OXATETRACYCLO[6.2.2.2(2,5).0(1,6)]TETRADECA-3,6-DIENE-11,11,12,12-TETRACARBONITRILE)IRON(O),[FE(C20H14N4O)(CO)3]
PILLOUD, F
ROULET, R
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1985, 41 (JUN) : 886 - 888

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